DISSEMINATED PERITONEAL LEIOMYOMATOSIS (DPL) is a very rare condition that almost always occurs in young women subjected to an altered hormonal milieu, usually pregnancy. To the surgeon, D00PL may appear as metastases; the possibility of DPL should be considered whenever PERITONEAL nodules are encountered in a young woman, particularly if she is pregnant. Here we present the case report of a 35-year-old woman with DPL, spontaneously regressing after total hysterectomy and bilateral salpingo-oophorectomy.

LEIOMYOMATOSIS PERITONEALis disseminata is a very rare condition characterized by the development of multiple smooth muscle-like nodules in the PERITONEAL cavity. It is associated with increased serum levels of gonadal steroids. The present report describes a 29-year-old patient underwent transabdominal hysterectomy and Bilateral Salpingo oophorectomy six years ago because of LEIOMYOMATOSIS PERITONEALis disseminata. After six years she referred to us again because of retroPERITONEAL fibroma, another rare entity, during hormone replacement therapy inspite of lack of uterus and previous castration.

DISSEMINATED PERITONEAL LEIOMYOMATOSIS (DPL) is a rare benign illness characterized by numerous smooth muscle nodules over the PERITONEAL surface of the abdomen and pelvis. It mostly occurs in women of reproductive age, seldom in the postmenopausal women and men. We herein report two DPL cases and both of them took 18F-FDG PET/ CT (Fluorine 18 Fluorodeoxyglucose Positron Emission Tomography) examination. On PET/CT images, all DPL nodules presented low to moderate metabolism, and the range of SUVmax (standard uptake value) was 1. 9 to 4. 4. An unusual diagnosis of DPL was difficult to make.

LEIOMYOMATOSIS PERITONEALis disseminata (LPD) is a benign disease characterized by the presence of multiple small nodules on the omentum, parietal, and visceral peritoneum. It corresponds to LEIOMYOMA and often resembles metastases of malignant tumors; however, with favorable prognosis. Here we describe a 46-year-old woman, diagnosed with LPD, to demonstrate the etiopathogenesis of the developed LEIOMYOMATOSIS following endoscopic extirpation of the uterus with the use of a power morcellator. The patient was operated for diffuse LEIOMYOMA using a power morcellator. Six months later, during a follow-up visit, DISSEMINATED tumor nodes on the peritoneum were revealed. Histological and immunohistochemical (smooth muscle α-actin, vimentin, estrogen receptors, progesterone receptors, and Ki67) study confirmed the diagnosis of LPD. As part of the follow-up, certain regression of the tumor nodes was noted against the backdrop of the onset of menopause and the corresponding decline of estrogen levels. Currently, the prognosis is favorable and follow-up is ongoing. Such cases are rare, but the condition is particularly important due to its iatrogenic nature. It has attracted the attention of the Food and Drug Administration (FDA) because power morcellation is probably associated with the risk of spreading suspected cancerous tissue. The existing high risk of iatrogenic LPD formation indicates the need for detailed reporting of all similar clinical cases, including the established pathogenetic and pathomorphological mechanisms of this process to prevent morcellator-related complications.

Intravenous LEIOMYOMATOSIS is a histologically benign smooth-muscle tumor arising from either a uterine myoma or the walls of a uterine vessel with extension into veins. We describe echocardiographic features of intravenous LEIOMYOMATOSIS with spread into the right-sideacardiac chambers. The patient was a middle-aged woman, with prior history of hysterectomy 2 years earlier who presented with cardiac symptoms and signs. Echocardiographic features included: 1) elongated mobile mass extending from the inferior vena cava, and 2) multiple masses in the right-heart chambers (right atrium and ventricle).Intracardiac LEIOMYOMATOSIS should be considered in a female patient presenting with an extensive mass in the right-sided cardiac chambers.

Intravenous LEIOMYOMATOSIS is an uncommon non-malignant tumor which originates from the smooth muscle cells. It is usually confined to the pelvic venous system. Rarely it can afflict intracaval and intracardiac extension. We report a case of young 25 years old woman, G2/P2; with intravenous LEIOMYOMATOSIS originate from the uterus and extending into right atrium. It was successfully treated through a two-stage surgical approac h. In conclusion, we should consider intravenous LEIOMYOMATOSIS with cardiac extension in patient with uterus LEIOMYOMA, hysterectomy, cardiac symptoms, and cardiac mass.

Herein, we report on a well-characterized benign metastasizing LEIOMYOMA, presented in an unusual site. Up to the knowledge of authors, so far, only 76 cases of benign metastasizing LEIOMYOMA have been reported. The tumor presented as a retroPERITONEAL mass three years after a hysterectomy Performed for LEIOMYOMATOSIS of the uterus with extensive areas of hyalinization. Histopathologic and immunohistochemical studies of the resected mass were similar to the uterine LEIOMYOMA, showing moderate cellularity of bland looking smooth muscle cells with minimal atypia, inconspicuous mitosis, and no necrosis in a hyalinized background.